Drug interactions
Diltiazem + Saxagliptin-metformin
Severity: Minor
Diltiazem and Saxagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem, a moderate CYP3A4 inhibitor, increases saxagliptin exposure by a limited amount. This is generally not clinically significant and no dose reduction is needed, unlike with strong inhibitors.
What this interaction means in plain words
Diltiazem and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diltiazem belongs to Cardiovascular; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Inhibition of CYP3A4/5 metabolism of saxagliptin.
What to do
No dose adjustment is required. Monitor glycemic response and tolerability.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin-metformin
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Diltiazem with Saxagliptin-metformin?
MediHelp rates the interaction as minor. Diltiazem and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Diltiazem, a moderate CYP3A4 inhibitor, increases saxagliptin exposure by a limited amount. This is generally not clinically significant and no dose reduction is needed, unlike with strong inhibitors.
How serious is the interaction between Diltiazem and Saxagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required. Monitor glycemic response and tolerability.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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