Drug interactions
Diltiazem + Sufentanil
Severity: Moderate
Diltiazem and Sufentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem may raise sufentanil concentrations and prolong its effects, and both can cause bradycardia and hypotension. Patients on chronic calcium channel blockers may have more pronounced hemodynamic effects during opioid anesthesia induction.
What this interaction means in plain words
Diltiazem and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Sufentanil belongs to Musculoskeletal.
Why it happens
Diltiazem inhibits CYP3A4 metabolism of sufentanil, with additive cardiovascular depressant effects.
What to do
Titrate sufentanil carefully with continuous hemodynamic monitoring, and be prepared to treat bradycardia and hypotension. Monitor for prolonged respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Diltiazem with Sufentanil?
MediHelp rates the interaction as moderate. Diltiazem and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem may raise sufentanil concentrations and prolong its effects, and both can cause bradycardia and hypotension. Patients on chronic calcium channel blockers may have more pronounced hemodynamic effects during opioid anesthesia induction.
How serious is the interaction between Diltiazem and Sufentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate sufentanil carefully with continuous hemodynamic monitoring, and be prepared to treat bradycardia and hypotension. Monitor for prolonged respiratory depression.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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