Drug interactions
Diltiazem + Treprostinil
Severity: Moderate
Diltiazem and Treprostinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Treprostinil is a potent vasodilator, and combining it with antihypertensive vasodilators such as diltiazem may increase the risk of symptomatic hypotension. The effect is generally modest and manageable.
What this interaction means in plain words
Diltiazem and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Treprostinil belongs to Cardiovascular.
Why it happens
Additive vasodilation and blood pressure lowering.
What to do
Monitor blood pressure and symptoms of hypotension when starting or titrating treprostinil, and reduce diltiazem dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Treprostinil
Frequently asked questions
Can I take Diltiazem with Treprostinil?
MediHelp rates the interaction as moderate. Diltiazem and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Treprostinil is a potent vasodilator, and combining it with antihypertensive vasodilators such as diltiazem may increase the risk of symptomatic hypotension. The effect is generally modest and manageable.
How serious is the interaction between Diltiazem and Treprostinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms of hypotension when starting or titrating treprostinil, and reduce diltiazem dose if needed.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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