Drug interactions
Diltiazem + Venetoclax
Severity: Major
Diltiazem and Venetoclax: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem can raise venetoclax exposure because venetoclax is cleared by CYP3A4. This increases the risk of neutropenia and tumor lysis syndrome.
What this interaction means in plain words
Diltiazem and Venetoclax can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Diltiazem belongs to Cardiovascular; Venetoclax belongs to Miscellaneous.
Why it happens
Diltiazem inhibits CYP3A4, reducing venetoclax clearance.
What to do
Avoid if possible. If it must be used, reduce the venetoclax dose by at least 50% and monitor blood counts and tumor lysis parameters.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Venetoclax
- Clarithromycin + Venetoclax Contraindicated
- Itraconazole + Venetoclax Contraindicated
- Ketoconazole + Venetoclax Contraindicated
- Posaconazole + Venetoclax Contraindicated
- Venetoclax + Voriconazole Contraindicated
- Amiodarone + Venetoclax Major
Frequently asked questions
Can I take Diltiazem with Venetoclax?
MediHelp rates the interaction as major. Diltiazem and Venetoclax can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Diltiazem can raise venetoclax exposure because venetoclax is cleared by CYP3A4. This increases the risk of neutropenia and tumor lysis syndrome.
How serious is the interaction between Diltiazem and Venetoclax?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If it must be used, reduce the venetoclax dose by at least 50% and monitor blood counts and tumor lysis parameters.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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