Drug interactions
Dimenhydrinate + Dosulepin
Severity: Moderate
Dimenhydrinate and Dosulepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin is a sedating, anticholinergic tricyclic antidepressant, and dimenhydrinate adds antihistaminic and anticholinergic effects. The combination can cause marked drowsiness, dry mouth, constipation, urinary retention and confusion.
What this interaction means in plain words
Dimenhydrinate and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dimenhydrinate belongs to Respiratory; Dosulepin belongs to Central Nervous System.
Why it happens
Additive H1-antihistaminic and antimuscarinic effects.
What to do
Use an alternative antiemetic or antihistamine with less anticholinergic activity where possible. If needed, monitor for anticholinergic toxicity and oversedation, especially in the elderly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dimenhydrinate and Dosulepin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dimenhydrinate
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Dimenhydrinate with Dosulepin?
MediHelp rates the interaction as moderate. Dimenhydrinate and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin is a sedating, anticholinergic tricyclic antidepressant, and dimenhydrinate adds antihistaminic and anticholinergic effects. The combination can cause marked drowsiness, dry mouth, constipation, urinary retention and confusion.
How serious is the interaction between Dimenhydrinate and Dosulepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antiemetic or antihistamine with less anticholinergic activity where possible. If needed, monitor for anticholinergic toxicity and oversedation, especially in the elderly.
What other medicines interact with Dimenhydrinate?
MediHelp also lists interactions of Dimenhydrinate with, for example, Belladonna and opium, Brexanolone, Calcium / magnesium / potassium / sodium oxybates. The full list is on the Dimenhydrinate page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
