Drug interactions
Dimenhydrinate + Fesoterodine
Severity: Moderate
Dimenhydrinate and Fesoterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dimenhydrinate is a first-generation antihistamine with strong anticholinergic activity. Together with fesoterodine it can cause additive dry mouth, constipation, urinary retention, blurred vision, sedation and confusion.
What this interaction means in plain words
Dimenhydrinate and Fesoterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dimenhydrinate belongs to Respiratory; Fesoterodine belongs to Genitourinary.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Avoid regular combined use in older adults and monitor for anticholinergic toxicity and sedation. Use short-term dimenhydrinate only when needed or choose a non-anticholinergic antiemetic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Other interactions of Dimenhydrinate
Frequently asked questions
Can I take Dimenhydrinate with Fesoterodine?
MediHelp rates the interaction as moderate. Dimenhydrinate and Fesoterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dimenhydrinate is a first-generation antihistamine with strong anticholinergic activity. Together with fesoterodine it can cause additive dry mouth, constipation, urinary retention, blurred vision, sedation and confusion.
How serious is the interaction between Dimenhydrinate and Fesoterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular combined use in older adults and monitor for anticholinergic toxicity and sedation. Use short-term dimenhydrinate only when needed or choose a non-anticholinergic antiemetic.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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