Drug interactions
Dimenhydrinate + Hyaluronidase
Severity: Minor
Dimenhydrinate and Hyaluronidase: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antihistamines given in large systemic doses have been reported to make tissues partially resistant to hyaluronidase. The spreading effect of hyaluronidase may therefore be reduced.
What this interaction means in plain words
Dimenhydrinate and Hyaluronidase have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dimenhydrinate belongs to Respiratory; Hyaluronidase belongs to Miscellaneous.
Why it happens
Antihistamines may antagonise the tissue permeability effects of hyaluronidase; the mechanism is not firmly established.
What to do
If hyaluronidase response is inadequate in a patient taking high-dose dimenhydrinate, a larger dose of hyaluronidase may be needed. No routine change is required at usual doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dimenhydrinate
Other interactions of Hyaluronidase
Frequently asked questions
Can I take Dimenhydrinate with Hyaluronidase?
MediHelp rates the interaction as minor. Dimenhydrinate and Hyaluronidase have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antihistamines given in large systemic doses have been reported to make tissues partially resistant to hyaluronidase. The spreading effect of hyaluronidase may therefore be reduced.
How serious is the interaction between Dimenhydrinate and Hyaluronidase?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If hyaluronidase response is inadequate in a patient taking high-dose dimenhydrinate, a larger dose of hyaluronidase may be needed. No routine change is required at usual doses.
What other medicines interact with Dimenhydrinate?
MediHelp also lists interactions of Dimenhydrinate with, for example, Belladonna and opium, Brexanolone, Calcium / magnesium / potassium / sodium oxybates. The full list is on the Dimenhydrinate page.
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