Drug interactions
Dimenhydrinate + Imipramine
Severity: Moderate
Dimenhydrinate and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dimenhydrinate releases diphenhydramine, a sedating antihistamine with strong anticholinergic effects. With imipramine it may cause considerable drowsiness and anticholinergic effects such as confusion, urinary retention, dry mouth and constipation.
What this interaction means in plain words
Dimenhydrinate and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dimenhydrinate belongs to Respiratory; Imipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression and antimuscarinic effects.
What to do
Avoid or minimize use in older adults, and monitor for sedation and anticholinergic symptoms. Counsel patients not to drive while symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Dimenhydrinate
Frequently asked questions
Can I take Dimenhydrinate with Imipramine?
MediHelp rates the interaction as moderate. Dimenhydrinate and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dimenhydrinate releases diphenhydramine, a sedating antihistamine with strong anticholinergic effects. With imipramine it may cause considerable drowsiness and anticholinergic effects such as confusion, urinary retention, dry mouth and constipation.
How serious is the interaction between Dimenhydrinate and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid or minimize use in older adults, and monitor for sedation and anticholinergic symptoms. Counsel patients not to drive while symptomatic.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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