Drug interactions
Dimenhydrinate + Lorazepam
Severity: Moderate
Dimenhydrinate and Lorazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dimenhydrinate is a sedating antihistamine, and combining it with lorazepam increases drowsiness, dizziness and impairment of psychomotor performance. Older adults are at particular risk of confusion and falls.
What this interaction means in plain words
Dimenhydrinate and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dimenhydrinate belongs to Respiratory; Lorazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression from benzodiazepine GABA-A potentiation and central H1 antagonism with anticholinergic effects.
What to do
Use the lowest effective doses and advise against driving or operating machinery. Avoid the combination in elderly patients where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Other interactions of Dimenhydrinate
Frequently asked questions
Can I take Dimenhydrinate with Lorazepam?
MediHelp rates the interaction as moderate. Dimenhydrinate and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dimenhydrinate is a sedating antihistamine, and combining it with lorazepam increases drowsiness, dizziness and impairment of psychomotor performance. Older adults are at particular risk of confusion and falls.
How serious is the interaction between Dimenhydrinate and Lorazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and advise against driving or operating machinery. Avoid the combination in elderly patients where possible.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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