Drug interactions
Dimenhydrinate + Morphine
Severity: Moderate
Dimenhydrinate and Morphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dimenhydrinate, which releases the sedating antihistamine diphenhydramine, adds to morphine's drowsiness and impairs alertness. Elderly patients are more susceptible to confusion and falls.
What this interaction means in plain words
Dimenhydrinate and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dimenhydrinate belongs to Respiratory; Morphine belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression.
What to do
Monitor for excessive sedation and use the lowest effective doses. Advise against driving or operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Dimenhydrinate
Frequently asked questions
Can I take Dimenhydrinate with Morphine?
MediHelp rates the interaction as moderate. Dimenhydrinate and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dimenhydrinate, which releases the sedating antihistamine diphenhydramine, adds to morphine's drowsiness and impairs alertness. Elderly patients are more susceptible to confusion and falls.
How serious is the interaction between Dimenhydrinate and Morphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and use the lowest effective doses. Advise against driving or operating machinery.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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