Drug interactions
Diphenhydramine + Nebivolol
Severity: Minor
Diphenhydramine and Nebivolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diphenhydramine inhibits CYP2D6 and may raise nebivolol concentrations. This may lead to enhanced beta-blockade with bradycardia or hypotension, especially in CYP2D6 extensive metabolizers.
What this interaction means in plain words
Diphenhydramine and Nebivolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diphenhydramine belongs to Respiratory; Nebivolol belongs to Cardiovascular.
Why it happens
Inhibition of CYP2D6-mediated nebivolol metabolism by diphenhydramine.
What to do
Monitor heart rate and blood pressure with regular diphenhydramine use and reduce nebivolol dose if bradycardia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Diphenhydramine
Frequently asked questions
Can I take Diphenhydramine with Nebivolol?
MediHelp rates the interaction as minor. Diphenhydramine and Nebivolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Diphenhydramine inhibits CYP2D6 and may raise nebivolol concentrations. This may lead to enhanced beta-blockade with bradycardia or hypotension, especially in CYP2D6 extensive metabolizers.
How serious is the interaction between Diphenhydramine and Nebivolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure with regular diphenhydramine use and reduce nebivolol dose if bradycardia occurs.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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