Drug interactions
Diphenoxylate-atropine + Dosulepin
Severity: Moderate
Diphenoxylate-atropine and Dosulepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin is a sedating tricyclic antidepressant with significant anticholinergic effects that overlap with atropine and opioid-related sedation. The combination may increase drowsiness, urinary retention, constipation and the risk of ileus.
What this interaction means in plain words
Diphenoxylate-atropine and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diphenoxylate-atropine belongs to Gastrointestinal Tract; Dosulepin belongs to Central Nervous System.
Why it happens
Additive anticholinergic and central nervous system depressant effects.
What to do
Monitor for sedation, urinary retention and abdominal distension, and avoid prolonged combined use in elderly patients. Counsel against driving until tolerance is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Diphenoxylate-atropine with Dosulepin?
MediHelp rates the interaction as moderate. Diphenoxylate-atropine and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin is a sedating tricyclic antidepressant with significant anticholinergic effects that overlap with atropine and opioid-related sedation. The combination may increase drowsiness, urinary retention, constipation and the risk of ileus.
How serious is the interaction between Diphenoxylate-atropine and Dosulepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, urinary retention and abdominal distension, and avoid prolonged combined use in elderly patients. Counsel against driving until tolerance is known.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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