Drug interactions
Diphenoxylate-atropine + Doxylamine
Severity: Moderate
Diphenoxylate-atropine and Doxylamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxylamine is a sedating antihistamine with anticholinergic activity. With diphenoxylate-atropine it may increase drowsiness, dry mouth, urinary retention and constipation.
What this interaction means in plain words
Diphenoxylate-atropine and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diphenoxylate-atropine belongs to Gastrointestinal Tract; Doxylamine belongs to Respiratory.
Why it happens
Additive sedative and anticholinergic effects.
What to do
Advise avoiding driving and alcohol, and monitor for anticholinergic adverse effects, especially in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Other interactions of Doxylamine
Frequently asked questions
Can I take Diphenoxylate-atropine with Doxylamine?
MediHelp rates the interaction as moderate. Diphenoxylate-atropine and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxylamine is a sedating antihistamine with anticholinergic activity. With diphenoxylate-atropine it may increase drowsiness, dry mouth, urinary retention and constipation.
How serious is the interaction between Diphenoxylate-atropine and Doxylamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise avoiding driving and alcohol, and monitor for anticholinergic adverse effects, especially in older adults.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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