Drug interactions
Diphenoxylate-atropine + Fesoterodine
Severity: Moderate
Diphenoxylate-atropine and Fesoterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents block muscarinic receptors, so combining them increases anticholinergic effects including dry mouth, constipation, urinary retention and blurred vision. Reduced gut motility from both may also contribute to ileus.
What this interaction means in plain words
Diphenoxylate-atropine and Fesoterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diphenoxylate-atropine belongs to Gastrointestinal Tract; Fesoterodine belongs to Genitourinary.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor for anticholinergic adverse effects and bladder emptying, and limit duration of the antidiarrheal. Avoid in patients with obstruction or narrow-angle glaucoma.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Other interactions of Fesoterodine
Frequently asked questions
Can I take Diphenoxylate-atropine with Fesoterodine?
MediHelp rates the interaction as moderate. Diphenoxylate-atropine and Fesoterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents block muscarinic receptors, so combining them increases anticholinergic effects including dry mouth, constipation, urinary retention and blurred vision. Reduced gut motility from both may also contribute to ileus.
How serious is the interaction between Diphenoxylate-atropine and Fesoterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and bladder emptying, and limit duration of the antidiarrheal. Avoid in patients with obstruction or narrow-angle glaucoma.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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