Drug interactions
Diphenoxylate-atropine + Oxybutynin
Severity: Moderate
Diphenoxylate-atropine and Oxybutynin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxybutynin is a potent antimuscarinic and adds to the atropine in diphenoxylate-atropine. This raises the risk of dry mouth, constipation, urinary retention, blurred vision, confusion, heat intolerance and reduced gut motility with possible ileus.
What this interaction means in plain words
Diphenoxylate-atropine and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diphenoxylate-atropine belongs to Gastrointestinal Tract; Oxybutynin belongs to Genitourinary.
Why it happens
Additive muscarinic receptor blockade.
What to do
Monitor for anticholinergic toxicity, particularly in older patients and those with obstructive bowel or urinary disease. Avoid the combination if ileus or retention develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Other interactions of Oxybutynin
Frequently asked questions
Can I take Diphenoxylate-atropine with Oxybutynin?
MediHelp rates the interaction as moderate. Diphenoxylate-atropine and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxybutynin is a potent antimuscarinic and adds to the atropine in diphenoxylate-atropine. This raises the risk of dry mouth, constipation, urinary retention, blurred vision, confusion, heat intolerance and reduced gut motility with possible ileus.
How serious is the interaction between Diphenoxylate-atropine and Oxybutynin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, particularly in older patients and those with obstructive bowel or urinary disease. Avoid the combination if ileus or retention develops.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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