Drug interactions
Diphenoxylate-atropine + Salmeterol
Severity: Minor
Diphenoxylate-atropine and Salmeterol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salmeterol is an inhaled beta-agonist and atropine can raise heart rate, so mild additive tachycardia is possible. There is no meaningful interaction with the opioid component, and the clinical effect is usually small.
What this interaction means in plain words
Diphenoxylate-atropine and Salmeterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diphenoxylate-atropine belongs to Gastrointestinal Tract; Salmeterol belongs to Respiratory.
Why it happens
Additive effects on heart rate from beta-agonism and vagal blockade.
What to do
No routine action is needed. Monitor heart rate in patients with cardiac disease.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Diphenoxylate-atropine with Salmeterol?
MediHelp rates the interaction as minor. Diphenoxylate-atropine and Salmeterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salmeterol is an inhaled beta-agonist and atropine can raise heart rate, so mild additive tachycardia is possible. There is no meaningful interaction with the opioid component, and the clinical effect is usually small.
How serious is the interaction between Diphenoxylate-atropine and Salmeterol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Monitor heart rate in patients with cardiac disease.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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