Drug interactions
Diphtheria and tetanus toxoids / acellular pertussis vaccine + Ustekinumab
Severity: Minor
Diphtheria and tetanus toxoids / acellular pertussis vaccine and Ustekinumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This non-live combination vaccine is safe with ustekinumab, and the immune response is expected to be largely preserved. A small reduction in titres is possible.
What this interaction means in plain words
Diphtheria and tetanus toxoids / acellular pertussis vaccine and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic: IL-12/23 inhibition may slightly reduce vaccine responses; not well characterized here.
What to do
Give the vaccine according to schedule; no adjustment is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Frequently asked questions
Can I take Diphtheria and tetanus toxoids / acellular pertussis vaccine with Ustekinumab?
MediHelp rates the interaction as minor. Diphtheria and tetanus toxoids / acellular pertussis vaccine and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. This non-live combination vaccine is safe with ustekinumab, and the immune response is expected to be largely preserved. A small reduction in titres is possible.
How serious is the interaction between Diphtheria and tetanus toxoids / acellular pertussis vaccine and Ustekinumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine according to schedule; no adjustment is required.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
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