Drug interactions
Dipipanone + Lidocaine-prilocaine
Severity: Minor
Dipipanone and Lidocaine-prilocaine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dipipanone is an opioid with sedative effects, and lidocaine absorbed systemically from a topical preparation may add a small degree of CNS depression. With typical topical use on intact skin systemic exposure is low, so the effect is usually negligible.
What this interaction means in plain words
Dipipanone and Lidocaine-prilocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive central nervous system depression from systemically absorbed local anesthetic and an opioid.
What to do
No routine action is needed with normal topical dosing. Avoid applying lidocaine-prilocaine over large areas, on broken skin, or under occlusion in patients receiving opioids, and watch for excess sedation if this happens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lidocaine-prilocaine
- Lidocaine-prilocaine + Phenazopyridine Major
- Bupivacaine implant + Lidocaine-prilocaine Moderate
- Bupivacaine liposome + Lidocaine-prilocaine Moderate
- Disopyramide + Lidocaine-prilocaine Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lidocaine-prilocaine Moderate
- Lidocaine-prilocaine + Mexiletine Moderate
Frequently asked questions
Can I take Dipipanone with Lidocaine-prilocaine?
MediHelp rates the interaction as minor. Dipipanone and Lidocaine-prilocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dipipanone is an opioid with sedative effects, and lidocaine absorbed systemically from a topical preparation may add a small degree of CNS depression. With typical topical use on intact skin systemic exposure is low, so the effect is usually negligible.
How serious is the interaction between Dipipanone and Lidocaine-prilocaine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed with normal topical dosing. Avoid applying lidocaine-prilocaine over large areas, on broken skin, or under occlusion in patients receiving opioids, and watch for excess sedation if this happens.
What other medicines interact with Lidocaine-prilocaine?
MediHelp also lists interactions of Lidocaine-prilocaine with, for example, Phenazopyridine, Bupivacaine implant, Bupivacaine liposome. The full list is on the Lidocaine-prilocaine page.
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