Drug interactions
Dipipanone + Maprotiline
Severity: Major
Dipipanone and Maprotiline: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dipipanone is a strong opioid, and combining it with sedating maprotiline can lead to marked drowsiness, respiratory depression and hypotension. Anticholinergic effects may also worsen constipation and urinary retention.
What this interaction means in plain words
Dipipanone and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression.
What to do
Use reduced starting doses and monitor sedation and respiratory rate, particularly after dose increases. Avoid alcohol and other sedatives.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Dipipanone with Maprotiline?
MediHelp rates the interaction as major. Dipipanone and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dipipanone is a strong opioid, and combining it with sedating maprotiline can lead to marked drowsiness, respiratory depression and hypotension. Anticholinergic effects may also worsen constipation and urinary retention.
How serious is the interaction between Dipipanone and Maprotiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use reduced starting doses and monitor sedation and respiratory rate, particularly after dose increases. Avoid alcohol and other sedatives.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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