Drug interactions
Dipyridamole + Ibrutinib
Severity: Moderate
Dipyridamole and Ibrutinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibrutinib impairs platelet function and is associated with bleeding. Combined with dipyridamole, bleeding risk may be increased.
What this interaction means in plain words
Dipyridamole and Ibrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dipyridamole belongs to Cardiovascular; Ibrutinib belongs to Oncology.
Why it happens
Additive pharmacodynamic platelet inhibition (BTK inhibition plus dipyridamole's antiplatelet effect).
What to do
Monitor for bruising and bleeding and check blood counts periodically. Review need for dipyridamole, and consider holding ibrutinib around surgery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dipyridamole
- Dipyridamole + Riociguat Contraindicated
- Adenosine + Dipyridamole Major
- Betrixaban + Dipyridamole Major
- Dabigatran + Dipyridamole Major
- Dipyridamole + Regadenoson Major
- Dipyridamole + Venetoclax Major
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Dipyridamole with Ibrutinib?
MediHelp rates the interaction as moderate. Dipyridamole and Ibrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibrutinib impairs platelet function and is associated with bleeding. Combined with dipyridamole, bleeding risk may be increased.
How serious is the interaction between Dipyridamole and Ibrutinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bruising and bleeding and check blood counts periodically. Review need for dipyridamole, and consider holding ibrutinib around surgery.
What other medicines interact with Dipyridamole?
MediHelp also lists interactions of Dipyridamole with, for example, Riociguat, Adenosine, Betrixaban. The full list is on the Dipyridamole page.
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