Drug interactions
Dipyridamole + Propranolol
Severity: Minor
Dipyridamole and Propranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dipyridamole raises adenosine levels, which can slow conduction, and propranolol adds beta-blocker effects on heart rate and AV conduction. Bradycardia is possible but infrequent with oral therapy. The effect is more relevant with intravenous dipyridamole stress testing.
What this interaction means in plain words
Dipyridamole and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dipyridamole belongs to Cardiovascular; Propranolol belongs to Cardiovascular.
Why it happens
Additive negative chronotropic effects from adenosine reuptake inhibition and beta blockade.
What to do
Monitor heart rate in patients with conduction disease. Be aware of bradycardia during intravenous dipyridamole testing.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Other interactions of Dipyridamole
- Dipyridamole + Riociguat Contraindicated
- Adenosine + Dipyridamole Major
- Betrixaban + Dipyridamole Major
- Dabigatran + Dipyridamole Major
- Dipyridamole + Regadenoson Major
- Dipyridamole + Venetoclax Major
Frequently asked questions
Can I take Dipyridamole with Propranolol?
MediHelp rates the interaction as minor. Dipyridamole and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dipyridamole raises adenosine levels, which can slow conduction, and propranolol adds beta-blocker effects on heart rate and AV conduction. Bradycardia is possible but infrequent with oral therapy. The effect is more relevant with intravenous dipyridamole stress testing.
How serious is the interaction between Dipyridamole and Propranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate in patients with conduction disease. Be aware of bradycardia during intravenous dipyridamole testing.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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