Drug interactions
Dipyridamole + Safinamide
Severity: Minor
Dipyridamole and Safinamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Safinamide and its main metabolite can inhibit intestinal BCRP, which may increase the absorption of BCRP substrates. Dipyridamole is not a well-established BCRP substrate, so any increase in its effect is speculative and likely small.
What this interaction means in plain words
Dipyridamole and Safinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dipyridamole belongs to Cardiovascular; Safinamide belongs to Central Nervous System.
Why it happens
Possible inhibition of intestinal BCRP efflux by safinamide, leading to higher exposure to substrates.
What to do
No dose change is expected; monitor for dipyridamole adverse effects such as headache, dizziness or hypotension if the combination is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dipyridamole
- Dipyridamole + Riociguat Contraindicated
- Adenosine + Dipyridamole Major
- Betrixaban + Dipyridamole Major
- Dabigatran + Dipyridamole Major
- Dipyridamole + Regadenoson Major
- Dipyridamole + Venetoclax Major
Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Dipyridamole with Safinamide?
MediHelp rates the interaction as minor. Dipyridamole and Safinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Safinamide and its main metabolite can inhibit intestinal BCRP, which may increase the absorption of BCRP substrates. Dipyridamole is not a well-established BCRP substrate, so any increase in its effect is speculative and likely small.
How serious is the interaction between Dipyridamole and Safinamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is expected; monitor for dipyridamole adverse effects such as headache, dizziness or hypotension if the combination is started.
What other medicines interact with Dipyridamole?
MediHelp also lists interactions of Dipyridamole with, for example, Riociguat, Adenosine, Betrixaban. The full list is on the Dipyridamole page.
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