Drug interactions
Dipyridamole + Topotecan
Severity: Moderate
Dipyridamole and Topotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dipyridamole inhibits P-gp and BCRP and may increase topotecan exposure, particularly oral topotecan. This may heighten myelosuppression and gastrointestinal toxicity.
What this interaction means in plain words
Dipyridamole and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dipyridamole belongs to Cardiovascular; Topotecan belongs to Oncology.
Why it happens
Inhibition of P-gp and BCRP efflux transporters raises topotecan absorption and systemic levels.
What to do
Avoid combining with oral topotecan where possible. With IV topotecan, monitor blood counts closely and adjust dosing for toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dipyridamole
- Dipyridamole + Riociguat Contraindicated
- Adenosine + Dipyridamole Major
- Betrixaban + Dipyridamole Major
- Dabigatran + Dipyridamole Major
- Dipyridamole + Regadenoson Major
- Dipyridamole + Venetoclax Major
Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporin + Topotecan Major
- Darunavir + Topotecan Major
Frequently asked questions
Can I take Dipyridamole with Topotecan?
MediHelp rates the interaction as moderate. Dipyridamole and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dipyridamole inhibits P-gp and BCRP and may increase topotecan exposure, particularly oral topotecan. This may heighten myelosuppression and gastrointestinal toxicity.
How serious is the interaction between Dipyridamole and Topotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining with oral topotecan where possible. With IV topotecan, monitor blood counts closely and adjust dosing for toxicity.
What other medicines interact with Dipyridamole?
MediHelp also lists interactions of Dipyridamole with, for example, Riociguat, Adenosine, Betrixaban. The full list is on the Dipyridamole page.
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