Drug interactions
Disulfiram + Dronabinol
Severity: Contraindicated
Disulfiram and Dronabinol: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronabinol oral solution contains substantial ethanol and propylene glycol. In patients taking disulfiram this can provoke a disulfiram-ethanol reaction with flushing, vomiting, palpitations and hypotension.
What this interaction means in plain words
Disulfiram and Dronabinol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Disulfiram inhibits aldehyde dehydrogenase, causing acetaldehyde accumulation from the ethanol in the solution.
What to do
Do not use dronabinol oral solution with disulfiram; allow a washout between them as labeled. Consider dronabinol capsules if appropriate.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Disulfiram and Dronabinol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Dronabinol
- Cefotetan + Dronabinol Contraindicated
- Dronabinol + Midazolam intranasal Major
- Dronabinol + Zuranolone Major
- Amobarbital + Dronabinol Moderate
- Apalutamide + Dronabinol Moderate
- Atazanavir + Dronabinol Moderate
Frequently asked questions
Can I take Disulfiram with Dronabinol?
MediHelp rates the interaction as contraindicated. Disulfiram and Dronabinol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Dronabinol oral solution contains substantial ethanol and propylene glycol. In patients taking disulfiram this can provoke a disulfiram-ethanol reaction with flushing, vomiting, palpitations and hypotension.
How serious is the interaction between Disulfiram and Dronabinol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use dronabinol oral solution with disulfiram; allow a washout between them as labeled. Consider dronabinol capsules if appropriate.
What other medicines interact with Dronabinol?
MediHelp also lists interactions of Dronabinol with, for example, Cefotetan, Midazolam intranasal, Zuranolone. The full list is on the Dronabinol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
