Drug interactions
Apalutamide + Dronabinol
Severity: Moderate
Apalutamide and Dronabinol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may reduce dronabinol levels, with potential loss of antiemetic or appetite-stimulating effect.
What this interaction means in plain words
Apalutamide and Dronabinol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Dronabinol belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 and CYP2C9 increases dronabinol metabolism.
What to do
Monitor symptom control and titrate dronabinol dose upward if effect is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Dronabinol
- Cefotetan + Dronabinol Contraindicated
- Disulfiram + Dronabinol Contraindicated
- Dronabinol + Midazolam intranasal Major
- Dronabinol + Zuranolone Major
- Amobarbital + Dronabinol Moderate
- Atazanavir + Dronabinol Moderate
Frequently asked questions
Can I take Apalutamide with Dronabinol?
MediHelp rates the interaction as moderate. Apalutamide and Dronabinol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide may reduce dronabinol levels, with potential loss of antiemetic or appetite-stimulating effect.
How serious is the interaction between Apalutamide and Dronabinol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control and titrate dronabinol dose upward if effect is lost.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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