Drug interactions
Cefotetan + Dronabinol
Severity: Contraindicated
Cefotetan and Dronabinol: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronabinol oral solution contains a large amount of ethanol, and cefotetan can cause disulfiram-like reactions with alcohol. Flushing, nausea, vomiting, tachycardia and hypotension may result.
What this interaction means in plain words
Cefotetan and Dronabinol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cefotetan belongs to Anti Bacterial; Dronabinol belongs to Central Nervous System.
Why it happens
Cefotetan inhibits aldehyde dehydrogenase, causing acetaldehyde accumulation from the ethanol in the dronabinol solution.
What to do
Do not use dronabinol oral solution with cefotetan or within several days of either drug. Use dronabinol capsules or another antiemetic if cefotetan is needed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Dronabinol
- Disulfiram + Dronabinol Contraindicated
- Dronabinol + Midazolam intranasal Major
- Dronabinol + Zuranolone Major
- Amobarbital + Dronabinol Moderate
- Apalutamide + Dronabinol Moderate
- Atazanavir + Dronabinol Moderate
Other interactions of Cefotetan
- Cefotetan + Warfarin Major
- Amikacin + Cefotetan Moderate
- Argatroban + Cefotetan Moderate
- Cefotetan + Dalteparin Moderate
- Cefotetan + Enoxaparin Moderate
- Cefotetan + Fondaparinux Moderate
Frequently asked questions
Can I take Cefotetan with Dronabinol?
MediHelp rates the interaction as contraindicated. Cefotetan and Dronabinol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Dronabinol oral solution contains a large amount of ethanol, and cefotetan can cause disulfiram-like reactions with alcohol. Flushing, nausea, vomiting, tachycardia and hypotension may result.
How serious is the interaction between Cefotetan and Dronabinol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use dronabinol oral solution with cefotetan or within several days of either drug. Use dronabinol capsules or another antiemetic if cefotetan is needed.
What other medicines interact with Dronabinol?
MediHelp also lists interactions of Dronabinol with, for example, Disulfiram, Midazolam intranasal, Zuranolone. The full list is on the Dronabinol page.
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