Drug interactions
Disulfiram + Dutasteride-tamsulosin
Severity: Minor
Disulfiram and Dutasteride-tamsulosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disulfiram may inhibit CYP2D6 and thus raise tamsulosin levels. This could increase dizziness and orthostatic hypotension.
What this interaction means in plain words
Disulfiram and Dutasteride-tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP2D6-mediated tamsulosin metabolism.
What to do
Monitor for postural hypotension and dizziness. Counsel patients to rise slowly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dutasteride-tamsulosin
Frequently asked questions
Can I take Disulfiram with Dutasteride-tamsulosin?
MediHelp rates the interaction as minor. Disulfiram and Dutasteride-tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Disulfiram may inhibit CYP2D6 and thus raise tamsulosin levels. This could increase dizziness and orthostatic hypotension.
How serious is the interaction between Disulfiram and Dutasteride-tamsulosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for postural hypotension and dizziness. Counsel patients to rise slowly.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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