Drug interactions
Disulfiram + Procarbazine
Severity: Moderate
Disulfiram and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine can cause a disulfiram-like reaction with alcohol and may also produce CNS effects. With disulfiram, there are case reports of delirium or psychosis, and effects on alcohol intolerance may be additive.
What this interaction means in plain words
Disulfiram and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mechanism not firmly established; possible additive CNS toxicity and aldehyde dehydrogenase related effects.
What to do
Monitor for confusion, agitation and altered mental status, and counsel strictly against alcohol. Consider alternatives if neuropsychiatric symptoms emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Disulfiram with Procarbazine?
MediHelp rates the interaction as moderate. Disulfiram and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine can cause a disulfiram-like reaction with alcohol and may also produce CNS effects. With disulfiram, there are case reports of delirium or psychosis, and effects on alcohol intolerance may be additive.
How serious is the interaction between Disulfiram and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for confusion, agitation and altered mental status, and counsel strictly against alcohol. Consider alternatives if neuropsychiatric symptoms emerge.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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