Drug interactions
Disulfiram + Tamsulosin
Severity: Minor
Disulfiram and Tamsulosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disulfiram may inhibit CYP2D6 and could increase tamsulosin exposure. The effect is not well characterized and probably modest.
What this interaction means in plain words
Disulfiram and Tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible CYP2D6 inhibition reducing tamsulosin metabolism.
What to do
Monitor for dizziness and orthostatic hypotension; no empirical dose change is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Frequently asked questions
Can I take Disulfiram with Tamsulosin?
MediHelp rates the interaction as minor. Disulfiram and Tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Disulfiram may inhibit CYP2D6 and could increase tamsulosin exposure. The effect is not well characterized and probably modest.
How serious is the interaction between Disulfiram and Tamsulosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness and orthostatic hypotension; no empirical dose change is required.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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