Drug interactions
Disulfiram + Tranylcypromine
Severity: Moderate
Disulfiram and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disulfiram has been associated with delirium, agitation and hallucinations when used with MAO inhibitors. The effect may be unpredictable and can complicate treatment of psychiatric or alcohol-related conditions.
What this interaction means in plain words
Disulfiram and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mechanism is not well established; disulfiram inhibits dopamine beta-hydroxylase, which may alter catecholamine balance with MAO inhibition.
What to do
Avoid the combination if possible, or monitor for confusion, agitation and hallucinations. Stop disulfiram if neuropsychiatric symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Disulfiram with Tranylcypromine?
MediHelp rates the interaction as moderate. Disulfiram and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Disulfiram has been associated with delirium, agitation and hallucinations when used with MAO inhibitors. The effect may be unpredictable and can complicate treatment of psychiatric or alcohol-related conditions.
How serious is the interaction between Disulfiram and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, or monitor for confusion, agitation and hallucinations. Stop disulfiram if neuropsychiatric symptoms develop.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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