Drug interactions
Divalproex + Ustekinumab
Severity: Minor
Divalproex and Ustekinumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ustekinumab may theoretically alter CYP450 activity as inflammation resolves, which could slightly change valproate levels. No clinically significant effect has been established.
What this interaction means in plain words
Divalproex and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical normalization of cytokine-suppressed CYP450 activity.
What to do
Consider checking valproate concentrations or seizure/mood control when starting or stopping ustekinumab if clinically indicated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Frequently asked questions
Can I take Divalproex with Ustekinumab?
MediHelp rates the interaction as minor. Divalproex and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ustekinumab may theoretically alter CYP450 activity as inflammation resolves, which could slightly change valproate levels. No clinically significant effect has been established.
How serious is the interaction between Divalproex and Ustekinumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider checking valproate concentrations or seizure/mood control when starting or stopping ustekinumab if clinically indicated.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
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