Drug interactions
Dobutamine + Eprosartan-hydrochlorothiazide
Severity: Moderate
Dobutamine and Eprosartan-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dobutamine can lower serum potassium through beta-2 stimulation, and combined with thiazide-induced potassium loss the risk of hypokalemia and arrhythmia increases. This matters most in critically ill or cardiac patients.
What this interaction means in plain words
Dobutamine and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dobutamine belongs to Cardiovascular; Eprosartan-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Beta-adrenergic stimulation shifts potassium into cells, adding to thiazide-induced renal potassium loss.
What to do
Monitor serum potassium and ECG during dobutamine infusion in patients taking a thiazide. Replace potassium to maintain normal levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Dobutamine
Frequently asked questions
Can I take Dobutamine with Eprosartan-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Dobutamine and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dobutamine can lower serum potassium through beta-2 stimulation, and combined with thiazide-induced potassium loss the risk of hypokalemia and arrhythmia increases. This matters most in critically ill or cardiac patients.
How serious is the interaction between Dobutamine and Eprosartan-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and ECG during dobutamine infusion in patients taking a thiazide. Replace potassium to maintain normal levels.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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