Drug interactions
Dobutamine + Hydralazine
Severity: Moderate
Dobutamine and Hydralazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dobutamine increases cardiac output and may add to hydralazine's vasodilation and reflex tachycardia. Net effects on blood pressure can vary, and the two drugs have partly opposing actions.
What this interaction means in plain words
Dobutamine and Hydralazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dobutamine belongs to Cardiovascular; Hydralazine belongs to Cardiovascular.
Why it happens
Pharmacodynamic interaction between beta-1 mediated inotropy and chronotropy and direct arteriolar vasodilation.
What to do
Monitor blood pressure, heart rate and rhythm during dobutamine infusion. Titrate each agent to hemodynamic goals.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Other interactions of Dobutamine
Frequently asked questions
Can I take Dobutamine with Hydralazine?
MediHelp rates the interaction as moderate. Dobutamine and Hydralazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dobutamine increases cardiac output and may add to hydralazine's vasodilation and reflex tachycardia. Net effects on blood pressure can vary, and the two drugs have partly opposing actions.
How serious is the interaction between Dobutamine and Hydralazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and rhythm during dobutamine infusion. Titrate each agent to hemodynamic goals.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
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