Drug interactions
Dobutamine + Rasagiline
Severity: Moderate
Dobutamine and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rasagiline is an MAO-B inhibitor that is selective at recommended doses but can lose selectivity at higher doses, potentially potentiating sympathomimetic amines. Dobutamine given to a patient on rasagiline could produce an exaggerated pressor or tachycardic response.
What this interaction means in plain words
Dobutamine and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dobutamine belongs to Cardiovascular; Rasagiline belongs to Central Nervous System.
Why it happens
MAO inhibition may reduce catecholamine metabolism and enhance sympathomimetic effects.
What to do
Start dobutamine at a low rate with continuous blood pressure and heart rate monitoring, and titrate cautiously to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dobutamine and Rasagiline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dobutamine
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Dobutamine with Rasagiline?
MediHelp rates the interaction as moderate. Dobutamine and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rasagiline is an MAO-B inhibitor that is selective at recommended doses but can lose selectivity at higher doses, potentially potentiating sympathomimetic amines. Dobutamine given to a patient on rasagiline could produce an exaggerated pressor or tachycardic response.
How serious is the interaction between Dobutamine and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start dobutamine at a low rate with continuous blood pressure and heart rate monitoring, and titrate cautiously to response.
What other medicines interact with Dobutamine?
MediHelp also lists interactions of Dobutamine with, for example, Budesonide-formoterol, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Dobutamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
