Drug interactions
Dobutamine + Sacubitril-valsartan
Severity: Moderate
Dobutamine and Sacubitril-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dobutamine can lower serum potassium through beta-2 stimulation, whereas the angiotensin receptor blocker tends to raise it, so the net effect is unpredictable. Both can influence blood pressure, and hypotension may occur in acutely ill patients.
What this interaction means in plain words
Dobutamine and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dobutamine belongs to Cardiovascular; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Beta-adrenergic-mediated intracellular potassium shift opposes angiotensin receptor blocker-related potassium retention; additive hemodynamic effects.
What to do
Monitor serum potassium and blood pressure during dobutamine infusion. Hold or reduce sacubitril-valsartan if hypotension or renal deterioration develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Dobutamine
Frequently asked questions
Can I take Dobutamine with Sacubitril-valsartan?
MediHelp rates the interaction as moderate. Dobutamine and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dobutamine can lower serum potassium through beta-2 stimulation, whereas the angiotensin receptor blocker tends to raise it, so the net effect is unpredictable. Both can influence blood pressure, and hypotension may occur in acutely ill patients.
How serious is the interaction between Dobutamine and Sacubitril-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure during dobutamine infusion. Hold or reduce sacubitril-valsartan if hypotension or renal deterioration develops.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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