Drug interactions
Docetaxel + Etrasimod
Severity: Major
Docetaxel and Etrasimod: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod lowers circulating lymphocytes and docetaxel suppresses bone marrow, so combined use may add to immunosuppression and infection risk. The combination has not been formally studied.
What this interaction means in plain words
Docetaxel and Etrasimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Docetaxel belongs to Oncology; Etrasimod belongs to Gastrointestinal Tract.
Why it happens
Additive immunosuppression: lymphocyte sequestration by etrasimod plus myelosuppression from docetaxel.
What to do
Avoid the combination where possible, and monitor for infection and check blood counts regularly if used together. Consider pausing etrasimod during chemotherapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Docetaxel
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Docetaxel with Etrasimod?
MediHelp rates the interaction as major. Docetaxel and Etrasimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etrasimod lowers circulating lymphocytes and docetaxel suppresses bone marrow, so combined use may add to immunosuppression and infection risk. The combination has not been formally studied.
How serious is the interaction between Docetaxel and Etrasimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, and monitor for infection and check blood counts regularly if used together. Consider pausing etrasimod during chemotherapy.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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