Drug interactions
Docetaxel + Istradefylline
Severity: Moderate
Docetaxel and Istradefylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At 40 mg daily istradefylline raises exposure to CYP3A4 and P-glycoprotein substrates, which could increase docetaxel levels. At 20 mg daily this effect was not seen.
What this interaction means in plain words
Docetaxel and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Docetaxel belongs to Oncology; Istradefylline belongs to Central Nervous System.
Why it happens
Dose-dependent inhibition of CYP3A4 and P-glycoprotein reduces docetaxel clearance.
What to do
Keep istradefylline at 20 mg daily if possible. Monitor blood counts and docetaxel toxicity, and reduce docetaxel if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Docetaxel and Istradefylline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Docetaxel
Other interactions of Istradefylline
Frequently asked questions
Can I take Docetaxel with Istradefylline?
MediHelp rates the interaction as moderate. Docetaxel and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At 40 mg daily istradefylline raises exposure to CYP3A4 and P-glycoprotein substrates, which could increase docetaxel levels. At 20 mg daily this effect was not seen.
How serious is the interaction between Docetaxel and Istradefylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep istradefylline at 20 mg daily if possible. Monitor blood counts and docetaxel toxicity, and reduce docetaxel if needed.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
