Drug interactions
Docetaxel + Nilotinib
Severity: Moderate
Docetaxel and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits P-glycoprotein and CYP3A4 to a modest degree, so docetaxel exposure may rise. Increased myelosuppression and other docetaxel toxicities are possible.
What this interaction means in plain words
Docetaxel and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Docetaxel belongs to Oncology; Nilotinib belongs to Oncology.
Why it happens
Nilotinib inhibits P-glycoprotein and weakly CYP3A4, potentially decreasing docetaxel clearance.
What to do
Monitor neutrophil counts and docetaxel adverse effects closely, and reduce the docetaxel dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Docetaxel
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Docetaxel with Nilotinib?
MediHelp rates the interaction as moderate. Docetaxel and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits P-glycoprotein and CYP3A4 to a modest degree, so docetaxel exposure may rise. Increased myelosuppression and other docetaxel toxicities are possible.
How serious is the interaction between Docetaxel and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts and docetaxel adverse effects closely, and reduce the docetaxel dose if toxicity develops.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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