Drug interactions
Docetaxel + Rufinamide
Severity: Minor
Docetaxel and Rufinamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rufinamide is a weak CYP3A4 inducer, so it could slightly lower docetaxel concentrations. The effect is expected to be small and is not well characterized in patients receiving docetaxel.
What this interaction means in plain words
Docetaxel and Rufinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Docetaxel belongs to Oncology; Rufinamide belongs to Central Nervous System.
Why it happens
Weak induction of CYP3A4 by rufinamide may modestly increase docetaxel metabolism.
What to do
No routine dose change is needed; monitor tumor response and docetaxel tolerance as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Docetaxel
Other interactions of Rufinamide
- Carbamazepine + Rufinamide Moderate
- Desogestrel-ethinyl estradiol + Rufinamide Moderate
- Dronedarone + Rufinamide Moderate
- Esketamine + Rufinamide Moderate
- Ethinyl estradiol-drospirenone + Rufinamide Moderate
- Ethinyl estradiol-levonorgestrel + Rufinamide Moderate
Frequently asked questions
Can I take Docetaxel with Rufinamide?
MediHelp rates the interaction as minor. Docetaxel and Rufinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rufinamide is a weak CYP3A4 inducer, so it could slightly lower docetaxel concentrations. The effect is expected to be small and is not well characterized in patients receiving docetaxel.
How serious is the interaction between Docetaxel and Rufinamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor tumor response and docetaxel tolerance as usual.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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