Drug interactions
Docetaxel + Sotorasib
Severity: Moderate
Docetaxel and Sotorasib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a weak inducer of CYP3A4 and interacts with P-glycoprotein, and docetaxel is cleared mainly by CYP3A4. Exposure to docetaxel could change, but the effect is not well characterized and is unlikely to be large. The legacy claim of a P-gp-mediated decrease is not firmly established.
What this interaction means in plain words
Docetaxel and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Docetaxel belongs to Oncology; Sotorasib belongs to Oncology.
Why it happens
Sotorasib may mildly induce CYP3A4 and modulate P-gp, potentially lowering docetaxel exposure; the magnitude is not established.
What to do
Monitor for reduced docetaxel efficacy and for neutropenia and other toxicities, and adjust the docetaxel dose based on clinical response and tolerance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Docetaxel
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Docetaxel with Sotorasib?
MediHelp rates the interaction as moderate. Docetaxel and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib is a weak inducer of CYP3A4 and interacts with P-glycoprotein, and docetaxel is cleared mainly by CYP3A4. Exposure to docetaxel could change, but the effect is not well characterized and is unlikely to be large. The legacy claim of a P-gp-mediated decrease is not firmly established.
How serious is the interaction between Docetaxel and Sotorasib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced docetaxel efficacy and for neutropenia and other toxicities, and adjust the docetaxel dose based on clinical response and tolerance.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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