Drug interactions
Docetaxel + Tolvaptan
Severity: Minor
Docetaxel and Tolvaptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolvaptan inhibits P-glycoprotein and could modestly increase exposure to docetaxel. The clinical significance is uncertain but increased docetaxel toxicity is possible.
What this interaction means in plain words
Docetaxel and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Docetaxel belongs to Oncology; Tolvaptan belongs to Endocrine.
Why it happens
Tolvaptan inhibits P-glycoprotein efflux, potentially reducing docetaxel clearance.
What to do
Monitor for docetaxel adverse effects, particularly neutropenia; no routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Docetaxel
Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Docetaxel with Tolvaptan?
MediHelp rates the interaction as minor. Docetaxel and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tolvaptan inhibits P-glycoprotein and could modestly increase exposure to docetaxel. The clinical significance is uncertain but increased docetaxel toxicity is possible.
How serious is the interaction between Docetaxel and Tolvaptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for docetaxel adverse effects, particularly neutropenia; no routine dose change is needed.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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