Drug interactions
Docetaxel + Trastuzumab
Severity: Moderate
Docetaxel and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab combined with docetaxel is a standard regimen, but it is associated with a higher incidence of neutropenia and febrile neutropenia than chemotherapy alone. Cardiac dysfunction is also a recognized trastuzumab toxicity.
What this interaction means in plain words
Docetaxel and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Docetaxel belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Additive pharmacodynamic myelosuppression; trastuzumab does not substantially alter docetaxel pharmacokinetics.
What to do
Monitor neutrophil counts and infection signs, using G-CSF support when appropriate, and monitor left ventricular ejection fraction regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Docetaxel
Other interactions of Trastuzumab
Frequently asked questions
Can I take Docetaxel with Trastuzumab?
MediHelp rates the interaction as moderate. Docetaxel and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab combined with docetaxel is a standard regimen, but it is associated with a higher incidence of neutropenia and febrile neutropenia than chemotherapy alone. Cardiac dysfunction is also a recognized trastuzumab toxicity.
How serious is the interaction between Docetaxel and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts and infection signs, using G-CSF support when appropriate, and monitor left ventricular ejection fraction regularly.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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