Drug interactions
Donepezil + Fluticasone-vilanterol
Severity: Moderate
Donepezil and Fluticasone-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Donepezil has been associated with QT prolongation and bradycardia, while vilanterol can cause tachycardia and hypokalemia. The combination could modestly raise arrhythmia risk in predisposed patients.
What this interaction means in plain words
Donepezil and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Donepezil belongs to Central Nervous System; Fluticasone-vilanterol belongs to Respiratory.
Why it happens
Additive effects on cardiac repolarization and heart rate; cholinesterase inhibition may also counter beta-agonist bronchodilation slightly.
What to do
Monitor ECG in patients with cardiac risk factors and check potassium if other risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Donepezil with Fluticasone-vilanterol?
MediHelp rates the interaction as moderate. Donepezil and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Donepezil has been associated with QT prolongation and bradycardia, while vilanterol can cause tachycardia and hypokalemia. The combination could modestly raise arrhythmia risk in predisposed patients.
How serious is the interaction between Donepezil and Fluticasone-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG in patients with cardiac risk factors and check potassium if other risk factors are present.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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