Drug interactions
Donepezil + Formoterol-mometasone
Severity: Moderate
Donepezil and Formoterol-mometasone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Donepezil is associated with QT prolongation and torsades de pointes, and formoterol may also prolong QTc. Combined use may add to arrhythmia risk, particularly with bradycardia or electrolyte disturbance.
What this interaction means in plain words
Donepezil and Formoterol-mometasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Donepezil belongs to Central Nervous System; Formoterol-mometasone belongs to Respiratory.
Why it happens
Additive QT prolongation through different pharmacodynamic mechanisms.
What to do
Correct potassium and magnesium and consider an ECG in patients with other QT risk factors. Monitor for palpitations or syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Formoterol-mometasone
Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Donepezil with Formoterol-mometasone?
MediHelp rates the interaction as moderate. Donepezil and Formoterol-mometasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Donepezil is associated with QT prolongation and torsades de pointes, and formoterol may also prolong QTc. Combined use may add to arrhythmia risk, particularly with bradycardia or electrolyte disturbance.
How serious is the interaction between Donepezil and Formoterol-mometasone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium and consider an ECG in patients with other QT risk factors. Monitor for palpitations or syncope.
What other medicines interact with Formoterol-mometasone?
MediHelp also lists interactions of Formoterol-mometasone with, for example, Amiodarone, Amisulpride, Amoxapine. The full list is on the Formoterol-mometasone page.
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