Drug interactions
Donepezil + Fostemsavir
Severity: Moderate
Donepezil and Fostemsavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostemsavir has caused QT prolongation at supratherapeutic doses, and donepezil has QT and bradycardia risk. At recommended fostemsavir doses the risk is small but may rise with other risk factors.
What this interaction means in plain words
Donepezil and Fostemsavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Donepezil belongs to Central Nervous System; Fostemsavir belongs to Anti Virals.
Why it happens
Possible additive QT prolongation.
What to do
Obtain an ECG in patients with cardiac disease or other QT-prolonging medications. Correct potassium and magnesium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Donepezil with Fostemsavir?
MediHelp rates the interaction as moderate. Donepezil and Fostemsavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fostemsavir has caused QT prolongation at supratherapeutic doses, and donepezil has QT and bradycardia risk. At recommended fostemsavir doses the risk is small but may rise with other risk factors.
How serious is the interaction between Donepezil and Fostemsavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG in patients with cardiac disease or other QT-prolonging medications. Correct potassium and magnesium.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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