Drug interactions
Donepezil + Histrelin
Severity: Moderate
Donepezil and Histrelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Histrelin, a GnRH agonist causing androgen deprivation, may prolong the QT interval. Donepezil has its own QT liability, so the combination may modestly raise arrhythmia risk.
What this interaction means in plain words
Donepezil and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Donepezil belongs to Central Nervous System; Histrelin belongs to Musculoskeletal.
Why it happens
Additive QT effects; androgen deprivation is associated with QT prolongation.
What to do
Check baseline ECG and electrolytes in patients with cardiac risk factors. Monitor for palpitations or syncope and review the need for donepezil if QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Donepezil with Histrelin?
MediHelp rates the interaction as moderate. Donepezil and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Histrelin, a GnRH agonist causing androgen deprivation, may prolong the QT interval. Donepezil has its own QT liability, so the combination may modestly raise arrhythmia risk.
How serious is the interaction between Donepezil and Histrelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes in patients with cardiac risk factors. Monitor for palpitations or syncope and review the need for donepezil if QTc lengthens.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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