Drug interactions
Donepezil + Imatinib
Severity: Minor
Donepezil and Imatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP2D6 and CYP3A4 to some degree, which could raise donepezil concentrations. This may increase cholinergic effects such as nausea, bradycardia or diarrhea, though the effect is probably small.
What this interaction means in plain words
Donepezil and Imatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Donepezil belongs to Central Nervous System; Imatinib belongs to Oncology.
Why it happens
Inhibition of CYP2D6 (and CYP3A4) by imatinib reduces donepezil metabolism.
What to do
Monitor heart rate and gastrointestinal tolerance when imatinib is started. Reduce the donepezil dose if cholinergic adverse effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Donepezil with Imatinib?
MediHelp rates the interaction as minor. Donepezil and Imatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Imatinib inhibits CYP2D6 and CYP3A4 to some degree, which could raise donepezil concentrations. This may increase cholinergic effects such as nausea, bradycardia or diarrhea, though the effect is probably small.
How serious is the interaction between Donepezil and Imatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and gastrointestinal tolerance when imatinib is started. Reduce the donepezil dose if cholinergic adverse effects emerge.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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