Drug interactions
Donepezil + Lapatinib
Severity: Moderate
Donepezil and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval. Used together they may add to the risk of torsades de pointes, particularly in patients with electrolyte disturbances, bradycardia or heart disease.
What this interaction means in plain words
Donepezil and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Donepezil belongs to Central Nervous System; Lapatinib belongs to Oncology.
Why it happens
Additive QT prolongation through effects on cardiac repolarization.
What to do
Obtain a baseline ECG and check potassium and magnesium before starting. Repeat the ECG periodically and stop or reassess if QTc rises markedly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Donepezil with Lapatinib?
MediHelp rates the interaction as moderate. Donepezil and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval. Used together they may add to the risk of torsades de pointes, particularly in patients with electrolyte disturbances, bradycardia or heart disease.
How serious is the interaction between Donepezil and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and check potassium and magnesium before starting. Repeat the ECG periodically and stop or reassess if QTc rises markedly.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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