Drug interactions
Donepezil + Levofloxacin
Severity: Moderate
Donepezil and Levofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Donepezil is associated with QT prolongation and torsades de pointes, and levofloxacin shares this liability. Using them together may raise the risk of serious ventricular arrhythmia, particularly with bradycardia or electrolyte disturbance.
What this interaction means in plain words
Donepezil and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Donepezil belongs to Central Nervous System; Levofloxacin belongs to Anti Bacterial.
Why it happens
Additive effects on cardiac repolarization, with donepezil also contributing bradycardia through cholinergic action.
What to do
Review for other QT-prolonging drugs and correct electrolytes. Obtain an ECG if the patient has syncope, palpitations or known cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Donepezil with Levofloxacin?
MediHelp rates the interaction as moderate. Donepezil and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Donepezil is associated with QT prolongation and torsades de pointes, and levofloxacin shares this liability. Using them together may raise the risk of serious ventricular arrhythmia, particularly with bradycardia or electrolyte disturbance.
How serious is the interaction between Donepezil and Levofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review for other QT-prolonging drugs and correct electrolytes. Obtain an ECG if the patient has syncope, palpitations or known cardiac disease.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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