Drug interactions
Donepezil + Prednisone
Severity: Minor
Donepezil and Prednisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prednisone is at most a weak CYP3A4 inducer and donepezil is metabolised by both CYP2D6 and CYP3A4, so a clinically significant reduction is unlikely. Any change in cognitive response would be small.
What this interaction means in plain words
Donepezil and Prednisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Donepezil belongs to Central Nervous System; Prednisone belongs to Endocrine.
Why it happens
Possible weak CYP3A4 induction; not well established.
What to do
No dose change is needed; reassess cognitive response if it appears to wane.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Donepezil with Prednisone?
MediHelp rates the interaction as minor. Donepezil and Prednisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Prednisone is at most a weak CYP3A4 inducer and donepezil is metabolised by both CYP2D6 and CYP3A4, so a clinically significant reduction is unlikely. Any change in cognitive response would be small.
How serious is the interaction between Donepezil and Prednisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; reassess cognitive response if it appears to wane.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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